Patent

I am a co-inventor on 11 U.S. patents and patent applications, 4 of which have been granted.

Granted

• F. Guo, J. Xu, and H. Cai. “Systems and methods for microneedle therapeutic delivery with acoustic signals.” U.S. Patent 12,721,986.
• F. Guo and H. Cai. “Methods and systems for dynamic control of an acoustic field.” U.S. Patent 12,649,133.
• F. Guo, Z. Ao, and H. Cai. “Methods for identifying and using cell behavior in drug screening and diagnosis.” U.S. Patent 12,456,194.
• F. Guo, Z. Ao, and H. Cai. “Open chamber acoustic device to measure cell binding force.” U.S. Patent 12,158,423.

Filed

• F. Guo and H. Cai. “Perfusable scaffolds for 3D cell cultures and methods of use.” U.S. Patent App. 19/252,737.
• F. Guo, K. Mackie, and H. Cai. “Intelligent closed-loop system for real-time reversal of acute disease.” U.S. Patent App. PCT/US2025/017276.
• F. Guo, H. Cai, and K. Mackie. “Acoustofluidic patch for sampling and delivery.” U.S. Patent App. 19/252,811.
• F. Guo, H. Cai, and Z. Ao. “Active electro-physiological system for determining function of biological neuronal networks.” U.S. Patent App. PCT/US2024/040483.
• F. Guo, H. Cai, and Z. Ao. “A method for rapid generation of 3D organotypic cell clusters.” U.S. Patent App. 18/835,051.
• F. Guo, H. Cai, and Z. Ao. “Device and methods for engineering and measuring flattened 3D cell cultures.” U.S. Patent App. 18/861,349.
• F. Guo, Z. Ao, and H. Cai. “A device having a support structure for creating a hollow, three-dimensional organoids and cultures.” U.S. Patent App. 18/272,455.

See the full Publication list, or view my CV.